1. Identify what physiological processes we should be paying attention to. Many physiological approaches were developed before the ‘omics revolution. Are we still measuring the best currencies? If so, can we measure them more efficiently? Can we currently leverage ‘omic measurements to estimate rates effectively?

2. Develop a framework and toolset for discovering proxies of physiological processes that can bridge ‘omics and models, leveraging expertise from physiologists, ‘omics researchers as well as cell and BGC modelers.

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The overarching aim of the WG is to identify and set the stage for the development of a core suite of measurements that are harmonized, low-cost, easy to use, and high throughput to promote co- measurement of ‘omics, rates, and BGC. Some of these will be new physiological measurements and some of these will be new ways to combine ‘omic measurements and cellular modeling approaches to understand physiology and improve the parametrization of larger scale models. The measure of success for this WG would be to bring co-design to fruition and establish a framework for the creation of physiological metrics that when implemented at scale and at low cost are broadly accessible.